I see, I thought this was something you made, the reason I asked about the extensions is because the only times I've encountered the "Object doesn't support this..." error is when I was making a custom extension and used their API incorrectly. But then it wouldn't work on any browser.
It is not uncommon that issues occur in IE and not in other browsers. The main reason for this is that Group Policies have been applied in IE, which then interfere with functionality. Symptomatically this issue would look more like a system side issue rather than Qlik Sense issue.
For further troubleshooting, Fiddler traces could reveal where the communication breaks and help identify the root cause. Ideally the Fiddler analysis would be done by comparing a successful access with a failed one.