Yes, it is, but in most cases it is probably easier to use the Mashup API. If you do this yourself you need to solve a bunch of problems yourself that are already solved in the lavascript library.
What do you want to do?? Do you need access to functions that are not exposed in the mashup API? Are you planning to do this in an environment where you cannot use the mashup API?
In addition you may want to take a look at these API videos that may help.
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