I opened a case in Qliktech and told me that Corruption can be caused by a lot of different issues. It can be caused by other software programs touching the file like antivirus. It can also be caused by network issues. It could be caused by a failed saved QVW. So We always have to make a backup in case of corruption.
I think that we should has always the last Release of QVS and QV Desktop.
Make the exceptions in our antivirus over the \program data\qliktech and all subfolders, Root folder, logs folder and all qvw folders.