Virtual Out Of Memory Error While Saving the Document
Hmmm... Kind of light on the RAM. I would think that there is something taking up some RAM and memory usage is moving over to a Page File. You PAge File must be small, or being used as well, and that is what is causing the issue. Try Comenting out as much data as you can, save, then move the file and see if that works. once the file is in its' new location, uncomment everything and refresh again.
Re: Virtual Out Of Memory Error While Saving the Document
I would suggest tuning the application.
Use QVOptimizer to determine which fields are using the most memory. See if you can reduce the memory usage on these fields (eg. if a timestamp is used and only the date portion is required, remove the time in the load scripts or see if you can split up uniuqe fields). I have attached a copy of QvOptimizer. Instructions on how to use it are on the Introduction sheet.
Also, go to robwunderlich.com and download documentanalyzer. This tool can be used to determine what fileds are actually used in the application. If a field is not used, remove it. This is a great tool. I use it all the time.