The QVS service is probably running, but cannot be contacted.
Is the QVS service running under the same account as the other QlikView services (on the server, run services.msc and scroll down. Services are listed alphabetically. Post a screenshot of those QlikView services with all columns visible).
Check out the QVS logs. Open the QVS Events log (not the Windows Events log) and see if that one contains a bit more information.
SPBITEST is part of the ACL through membership of the Administrators group. Does the security for a specific file in Documents (like CalData.pgo) include Administrators as well?
A Document Root can be changed manually by shutting QlikView services, copying/moving the contents of the Documents folder to a new location (check the parmissions of this new location), changing the old location to the new in C:\ProgramData\QlikTech\QlikViewServer\Settings.ini (key DocumentDirectory) and restarting the QV services.