I'm expirencing almost the same problem, in my case i'm trying to read a QVD file.on a 64Bit Windows 2012.
LUA_QVD-0004-A: QVB COM Server Initialization Error: Read-QVD CreateInstance failed (Interface not registered)
I suspect is the O.S. since i have the same project on a Win7 64bit machine, and it works perfectly.
So far I already unistal QVB and Expressor, reboot machine, install Expressor and no joy. All keep you posted if I find anything else.