Was able to fix this issue if anyone runs in to the same problem.
Appears the TLS Handshake error is due to errors in communication between NPrinting and the source system (Qlik Sense or Qlikview). To fix this we went through a full reinstall of all three NPrinting programs (server, engine, designer)
Please ensure when installing, that the user installing the tools is using a service account logged on the machine, has Administrator rights on the machine that the tools are being installed on, as well as 'Log on as Service Rights' enabled. Not to mention is a RootAdmin in Qlikview or Qlik Sense.
Although, we THOUGHT we were following the installation directions to a T, when installing i was using my Windows User logged on to our NPrinting Machine, and entering in the Service Account credentials when prompted, we received the error. So please be sure that you are logged on to the machine as the service account username when completing the installation process.
This seemed to fix our issue.