It's been a year since I had to manage a Qlik Sense site, but since Qlik Sense does not use a web server anymore (i.e.: no HTTP reqs but websockets) when I had to do this I did at a lower level
- with an additional proxy/load balancer or via firewall rule (e.g.: a rule for which requests for URL https://sense.domain.com are sent to IP 10.0.1.43:*)
- specifying in the DNS of the AD to which IP address the requests have to be sent to for the name of the host
Thinking out loud, I have not tested whether the port definitions in the QMC can use the form address:port instead of only port.
If there is a setting either in the QMC or in a ini or xml settings file in the current version equivalent to IIS "Bindings..." Levi or bbt can for sure let us know.