How many rows of data are you trying to display these calculated dimensions on? Can you limit the output to not display so many records simultaneously? i.e. make a selection or two in one of your non-calculated dimensions?
Another thought, but it sounds to me like a synthetic key issue that is chewing up all your resources maybe? Check your data layout and see how many row's are being calculated for any synthetic keys within the app.
The scheme is very simple, the main table has about 28,000 rows and it’s linked to an employee table with about 1000 rows.
There is only one linked field and I tried it with a reduced dataset but was getting the same problem.
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Are you using now() in any object in your interface?
This functions is continously refreshed (every second) and it causes the whole sheet to be updated.
This may not cause any troube if your interface has only 'light' expressions... you would only notice this in cases like yours.
Hope this helps,