I checked the options and all of them are exactly as in your screenshot.
We upgraded to QV11 SR2 about 4 months ago and since then everything was working fine with saving document and user reloads etc, till the server patching
(Microsoft security patches for .NET4.0 framework and other office updates).
Also, I can open the files and make modifications. It is only while saving thos e files that Access Denied message shows up.