Make sure the binding of the default website is pointed away from the port of the Qlikview Server. If the AccessPoint runs on port 80 move the IIS setting to e.g. 8080.
Please adjust the mail settings in the QMC: System > Mail Server
Hostname: localhost
Port: 25
From address: your office 365 mail adress
Authentication Method: Anonymous
Send all e-mails to: your prefered receiver adress(es)
In the Qlikview document if using alerts, make sure options batch and interactive are checked.