It's a silly suggestion but I would restart the whole server(s). I mean not only the qv-server also the os-server and/or the file-server. I have had recently a similar strange case where various files were blocked because the NTFS meta-stream hadn't released the files after closing them and exit/kill the process.
The user session were open when we made the deploy of file.
Solution:
After several researches, unfortunately, the solution was to restore the backup file qvw. But, before we exclude and replace without user is accessing the application.
