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can i do this with set analysis where the data containing the following keywords be grouped as opioid and just display the others as it is
Don't think so, The better way to do is in the script like below -
If(wildmatch(Medicine,'*FENTANYL*', '*HYDROMORPHONE*', '*MORPHINE*', '*OXYCODON'),'OpioidMedicines', Medicine) as Medicine_Formatted