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Is it compulsory to resolve synthetic keys
No
Haha, that's kind of a loaded question
Read this if you want to learn all about it: http://community.qlik.com/blogs/qlikviewdesignblog/2013/04/16/synthetic-keys and Should We Stop Worrying and Love the Synthetic Key?
TLDR would be this: it's not mandatory, but still it's a rather good idea.
It depends.
Some are perfectly ok, like those created by IntervalMatch
Some are a symptom of sloppy scripting
Others are disastrous
So your question is like the infamous "how long is a piece of string ?"