Qlik Sense is web based and is device agnostic. Web applications cannot access local file systems - you cannot read or write files to an arbitrary folder (for example: 'My Documents' or 'My Pictures'); Web Browsers limit this is by design.
For example, read the security section here:
"scripts run in a sandbox in which they can only perform Web-related actions, not general-purpose programming tasks like creating files"
If you have a webserver on the deployment machine, publish the .PDF file to a folder that is shared on the webserver for access via a URL.
For example, let say your machine is called DocServer, and the folder is called Docs. The URL for access then would be something like: http://DocServer/Docs/pdfdocumentname.pdf.
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