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I suggest to not create too complex set analysis, it'll make you analysis slower.
Create a new field during load script like
Load *
If(Col1<>Col2 and Col2<>Col3 and Col1<>Col3,1,0) as OnlyDistinct
From....
Then use this field in your expression:
Sum((Col+Col2+Col3)*OnlyDistinct)
or
Sum({<OnlyDistinct={1}>}Col+Col2+Col3)