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This is most likely database locking. I suspect the "email_addresses" table you've circled is using a different session than the "email_addresses" table near the bottom of the job.
go through all of your DB input/outputs and make sure they are using an existing connection-- your tMysqlConnection_1
Exception in component tMysqlOutput_9
com.mysql.jdbc.exceptions.jdbc4.MySQLNonTransientConnectionException: No operations allowed after statement closed.
at sun.reflect.NativeConstructorAccessorImpl.newInstance0(Native Method) ...