QRS API URL - multi-node setup

[#1]

As per https://help.qlik.com/en-US/sense-developer/2.1/Subsystems/RepositoryServiceAPI/Content/RepositorySe...‌there are 2 was of communicating with QRS APIs:

1. https://<QRS machine name>:4242/<path>

2. https://<proxy machine name>/<path> (When communicating via the proxy service)

Is one way preferred over other?

In the multi-node setup, is it ok to make QRS API calls to Central Node's 4242 port? We faced some replication issues doing it this way, is it expected?