You can try to generate a log file to check what is going on...
You can enable it at document properties -> General Tab -> Generate log file (on the right).
Then, during reload a file with the same name of your qvw will be generate with the extension .log at the same folder as your .qvw.
I had a problem like this before when the application became read-only or when I did not have the rights to write on the folder.
QlikView tried to save the application before reload and it crashed, or it tried to create a log file and failed, or tried to overwrite the log file... Maybe thats your problem...
Hope this helps,